SCG-Drug is a web service that can help researchers to predict potential activities of drugs of interest with respect to their genetic information using the systems chemical genetics method.
Genetic disease genes are considered a promising source of drug targets. Most diseases are caused by more than one pathogenic factor; thus, it is reasonable to consider that chemical agents targeting multiple disease genes are more likely to have desired activities. This is supported by a comprehensive analysis on the relationships between agent activity/druggability and target genetic characteristics. The therapeutic potential of agents increases steadily with increasing number of targeted disease genes, and can be further enhanced by strengthened genetic links between targets and diseases.
By using the multi-label machine-learning models for genetics-based drug activity prediction, we provide universal tools for prioritizing drug candidates. Learn more about SCG-Drug.