| Gene Information | |
|---|---|
| Gene Name | p27 |
| Organism | Homo sapiens (Human) |
| Gene Length | 198 |
| Protein Names | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P46527 |
| Gene Card | CDKN1B |
| Uniprot ID | P46527 |
| Pfam | PF02234 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in kidney (at protein level) (PubMed:15509543). Expressed in all tissues tested (PubMed:8033212). Highest levels in skeletal muscle, lowest in liver and kidney (PubMed:8033212). {ECO:0000269|PubMed:15509543, ECO:0000269|PubMed:8033212}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.219302(Rat);0.137946(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1H27 (X-ray 2.20A ) 1JSU (X-ray 2.30A ) 2AST (X-ray 2.30A ) 5UQ3 (X-ray 3.60A ) 6ATH (X-ray 1.82A ) 6P8E (X-ray 2.30A ) 6P8F (X-ray 2.89A ) 6P8G (X-ray 2.80A ) 7B5L (EM 3.80A ) 7B5M (EM 3.91A ) 7B5R (EM 3.80A ) 7OR8 (X-ray 1.80A ) 7ORG (X-ray 1.80A ) 7ORH (X-ray 1.80A ) 7ORS (X-ray 1.80A ) 7ORT (X-ray 2.33A ) |
| DBSNP | rs2066828 rs777354267 rs2066827 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Endosome {ECO:0000250}. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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