Gene Information
Gene NameTGFB1
OrganismHomo sapiens (Human)
Gene Length390
Protein NamesTransforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Target Nametransforming growth factor beta 1
Target TypeSuccessful target
Gene Age168 ( ENSG00000105329 )
Evolutionary StageEumetazoa
AlphaFoldDBP01137
Gene CardTGFB1
Uniprot IDP01137
PfamPF00019; PF00688
In ASDno
Allosteric Predictionyes (1.578359622)
Ortholog in AnimalsAlpaca_ TGFB1 ( ortholog_one2one )
Dog_ TGFB1 ( ortholog_one2one )
GuineaPig_ TGFB1 ( ortholog_one2one )
Macaque_ TGFB1 ( ortholog_one2one )
Mouse_ Tgfb1 ( ortholog_one2one )
Pig_ TGFB1 ( ortholog_one2one )
Rat_ Tgfb1 ( ortholog_one2one )
OhnologsTGFB2, TGFB3
ParalogsBMP3, MSTN, INHBC, GDF15, BMP6, INHBA, GDF6, TGFB3, BMP2, BMP10, INHA, GDF9, GDF11, BMP5, BMP7, INHBB, GDF5, GDF1, GDF2, BMP4, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, TGFB2, BMP8A, BMP8B, NODAL
TissueNA
Tissue SpecificityHighly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158). {ECO:0000269|PubMed:11746498, ECO:0000269|PubMed:17827158}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1KLA  (NMR  -  )  1KLC  (NMR  -  )  1KLD  (NMR  -  )  3KFD  (X-ray  3.00A  )  4KV5  (X-ray  3.00A  )  5FFO  (X-ray  3.49A  )  5VQP  (X-ray  2.90A  )  6OM2  (X-ray  2.77A  )  6P7J  (X-ray  3.50A  )  7Y1R  (EM  4.01A  )  7Y1T  (EM  3.24A  ) 
DBSNP rs1800470  rs1800471  rs1800472 
Subcellular location [CC][Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}.;
[Transforming growth factor beta-1]: Secreted {ECO:0000269|PubMed:17827158, ECO:0000269|PubMed:29483653}.
Mouse PG classificationHPG
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