| Gene Information | |
|---|---|
| Gene Name | CCR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 374 |
| Protein Names | C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192) |
| Target Name | c-c chemokine receptor type 2 |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000121807 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P41597 |
| Gene Card | CCR2 |
| Uniprot ID | P41597 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.245967233) |
| Ortholog in Animals | Alpaca_ CCR2 ( ortholog_one2one ) Dog_ CCR2 ( ortholog_one2one ) Macaque_ CCR2 ( ortholog_one2one ) Mouse_ Ccr2 ( ortholog_one2one ) Pig_ CCR2 ( ortholog_one2one ) Rat_ Ccr2 ( ortholog_one2one ) |
| Ohnologs | CCR7, CCR10, CXCR3, ACKR3, CXCR1, CXCR2 |
| Paralogs | CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3, GALR2, XCR1, RGR, ACKR3, CCR5, CCRL2, CCR1, CCR3, CCR4, CCR8, CX3CR1, ACKR2 |
| Tissue | NA |
| Tissue Specificity | Expressed by monocytes and IL2-activated NK cells. {ECO:0000269|PubMed:9058802}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2MLO (NMR - ) 2MLQ (NMR - ) 5T1A (X-ray 2.81A ) 7P8X (X-ray 1.40A ) 7XA3 (EM 2.90A ) |
| DBSNP | rs4987052 rs1799864 rs3918387 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:18587271}; Multi-pass membrane protein {ECO:0000255}. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. {ECO:0000269|PubMed:15995708}. |
| Mouse PG classification | NA |
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