| Gene Information | |
|---|---|
| Gene Name | ZTL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 765 |
| Protein Names | Proton-coupled zinc antiporter SLC30A5 (Solute carrier family 30 member 5) (Zinc transporter 5) (ZnT-5) (ZnT-like transporter 1) (hZTL1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8TAD4 |
| Gene Card | SLC30A5 |
| Uniprot ID | Q8TAD4 |
| Pfam | PF01545 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (PubMed:11904301, PubMed:12095919). Highly expressed in pancreas, liver and kidney (PubMed:11904301). Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells (at protein level) (PubMed:11904301). {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:12095919}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:12095919, ECO:0000269|PubMed:15525635, ECO:0000269|PubMed:21887337, ECO:0000269|PubMed:22529353}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:15525635}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:11904301}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19366695}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in early compartments of the secretory pathway including COPII-coated vesicles and the Golgi cis cisterna. {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:15525635}.; [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21887337}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:17355957}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11937503}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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