| Gene Information | |
|---|---|
| Gene Name | SMAD5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 465 |
| Protein Names | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000113658 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99717 |
| Gene Card | SMAD5 |
| Uniprot ID | Q99717 |
| Pfam | PF03165; PF03166 |
| In ASD | no |
| Allosteric Prediction | yes (0.022325439) |
| Ortholog in Animals | Alpaca_ SMAD5 ( ortholog_one2one ) Dog_ SMAD5 ( ortholog_one2one ) GuineaPig_ SMAD5 ( ortholog_one2one ) Macaque_ SMAD5 ( ortholog_one2one ) Mouse_ Smad5 ( ortholog_one2one ) Pig_ SMAD5 ( ortholog_one2one ) Rat_ Smad5 ( ortholog_one2one ) Rabbit_ SMAD5 ( ortholog_one2one ) |
| Ohnologs | SMAD9, SMAD3, SMAD2, SMAD1 |
| Paralogs | SMAD6, SMAD2, SMAD3, SMAD4, SMAD7, SMAD1, SMAD9 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001823(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6FZS (X-ray 2.31A ) 6TCE (X-ray 2.92A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. |
| Mouse PG classification | NA |
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