| Gene Information | |
|---|---|
| Gene Name | SPEN |
| Organism | Homo sapiens (Human) |
| Gene Length | 3664 |
| Protein Names | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000065526 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | SPEN |
| Uniprot ID | Q96T58 |
| Pfam | PF00076; PF07744 |
| In ASD | no |
| Allosteric Prediction | no (-0.427915113) |
| Ortholog in Animals | Alpaca_ SPEN ( ortholog_one2one ) Dog_ SPEN ( ortholog_one2one ) GuineaPig_ SPEN ( ortholog_one2one ) Macaque_ SPEN ( ortholog_one2one ) Mouse_ Spen ( ortholog_one2one ) Rat_ Spen ( ortholog_one2one ) Rabbit_ SPEN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAVER2, RBM15B, NONO, RAVER1, SFPQ, PSPC1, RBM15 |
| Tissue | NA |
| Tissue Specificity | Expressed at high level in brain, testis, spleen and thymus. Expressed at intermediate level in kidney, liver, mammary gland and skin. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OW1 (X-ray 1.80A ) 2RT5 (NMR - ) 4P6Q (X-ray 2.00A ) |
| DBSNP | rs848208 rs848209 rs12095818 rs848210 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11331609}. Note=Associates with chromatin. |
| Mouse PG classification | NA |
| click here to return to the previous page | |