| Gene Information | |
|---|---|
| Gene Name | ZRANB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1079 |
| Protein Names | DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000121988 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q5FWF4 |
| Gene Card | ZRANB3 |
| Uniprot ID | Q5FWF4 |
| Pfam | PF00271; PF01844; PF00176; PF00641 |
| In ASD | no |
| Allosteric Prediction | no (-1.026289932) |
| Ortholog in Animals | Alpaca_ ZRANB3 ( ortholog_one2one ) Dog_ ZRANB3 ( ortholog_one2one ) Macaque_ ZRANB3 ( ortholog_one2one ) Mouse_ Zranb3 ( ortholog_one2one ) Pig_ ZRANB3 ( ortholog_one2one ) Rat_ Zranb3 ( ortholog_one2one ) Rabbit_ ZRANB3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5MKW (X-ray 2.00A ) 5MLO (X-ray 1.96A ) 5MLW (X-ray 2.45A ) 5YD8 (X-ray 2.30A ) |
| DBSNP | rs935615 rs7608121 rs59900519 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:22704558, ECO:0000269|PubMed:22705370, ECO:0000269|PubMed:22759634}. Chromosome {ECO:0000269|PubMed:22704558, ECO:0000269|PubMed:22705370, ECO:0000269|PubMed:22759634}. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA (PubMed:22704558, PubMed:22705370, PubMed:22759634). {ECO:0000269|PubMed:22704558, ECO:0000269|PubMed:22705370, ECO:0000269|PubMed:22759634}. |
| Mouse PG classification | NA |
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