| Gene Information | |
|---|---|
| Gene Name | ZPR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 459 |
| Protein Names | Zinc finger protein ZPR1 (Zinc finger protein 259) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000109917 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | O75312 |
| Gene Card | ZPR1 |
| Uniprot ID | O75312 |
| Pfam | PF03367 |
| In ASD | no |
| Allosteric Prediction | yes (0.1807577) |
| Ortholog in Animals | Alpaca_ ZPR1 ( ortholog_one2many ) Dog_ ZPR1 ( ortholog_one2one ) GuineaPig_ ZPR1 ( ortholog_one2one ) Macaque_ ZPR1 ( ortholog_one2one ) Mouse_ Zpr1 ( ortholog_one2one ) Pig_ ZPR1 ( ortholog_one2one ) Rat_ Zpr1 ( ortholog_one2one ) Rabbit_ ZPR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients. {ECO:0000269|PubMed:22422766}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35120633 |
| Subcellular location [CC] | Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner. {ECO:0000250}. |
| Mouse PG classification | NA |
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