| Gene Information | |
|---|---|
| Gene Name | ZPK |
| Organism | Homo sapiens (Human) |
| Gene Length | 859 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q12852 |
| Gene Card | MAP3K12 |
| Uniprot ID | Q12852 |
| Pfam | PF07714 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain and kidney. {ECO:0000269|PubMed:8037767}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5CEN (X-ray 1.70A ) 5CEO (X-ray 2.28A ) 5CEP (X-ray 1.99A ) 5CEQ (X-ray 1.91A ) 5VO1 (X-ray 2.45A ) 5VO2 (X-ray 2.96A ) |
| DBSNP | rs34366500 rs55794887 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q60700}. Cell membrane {ECO:0000250|UniProtKB:Q60700}. Note=Behaves essentially as an integral membrane protein. {ECO:0000250|UniProtKB:Q60700}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |