| Gene Information | |
|---|---|
| Gene Name | ZNRF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 242 |
| Protein Names | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000180233 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8NHG8 |
| Gene Card | ZNRF2 |
| Uniprot ID | Q8NHG8 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.62527197) |
| Ortholog in Animals | Alpaca_ ZNRF2 ( ortholog_one2one ) Dog_ ZNRF2 ( ortholog_one2one ) Macaque_ ZNRF2 ( ortholog_one2many ) Mouse_ Znrf2 ( ortholog_one2one ) Pig_ ZNRF2 ( ortholog_one2one ) Rat_ Znrf2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNF11, ZNRF1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney. {ECO:0000269|PubMed:14561866}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Lysosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Presynaptic cell membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. |
| Mouse PG classification | NA |
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