| Gene Information | |
|---|---|
| Gene Name | ZNRF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 227 |
| Protein Names | E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000186187 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8ND25 |
| Gene Card | ZNRF1 |
| Uniprot ID | Q8ND25 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.642556717) |
| Ortholog in Animals | Alpaca_ ZNRF1 ( ortholog_one2one ) Dog_ ZNRF1 ( ortholog_one2one ) GuineaPig_ ZNRF1 ( ortholog_one2one ) Macaque_ ZNRF1 ( ortholog_one2one ) Mouse_ Znrf1 ( ortholog_one2one ) Pig_ ZNRF1 ( ortholog_one2one ) Rat_ Znrf1 ( ortholog_one2one ) Rabbit_ ZNRF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNF11, ZNRF2 |
| Tissue | NA |
| Tissue Specificity | Expressed primarily in the nervous system, with expression higher in developing brain relative to adult. Expressed at low levels in testis and thymus. {ECO:0000269|PubMed:11427537, ECO:0000269|PubMed:14561866}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.025000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5YWR (X-ray 1.47A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Associated with synaptic vesicle membranes in neurons. |
| Mouse PG classification | NA |
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