| Gene Information | |
|---|---|
| Gene Name | SYMPK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1274 |
| Protein Names | Symplekin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000125755 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92797 |
| Gene Card | SYMPK |
| Uniprot ID | Q92797 |
| Pfam | PF11935; PF12295 |
| In ASD | no |
| Allosteric Prediction | no (-0.705766694) |
| Ortholog in Animals | Alpaca_ SYMPK ( ortholog_one2one ) Dog_ SYMPK ( ortholog_one2one ) GuineaPig_ SYMPK ( ortholog_one2one ) Macaque_ SYMPK ( ortholog_one2one ) Mouse_ Sympk ( ortholog_one2one ) Pig_ SYMPK ( ortholog_one2one ) Rat_ Sympk ( ortholog_one2one ) Rabbit_ SYMPK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts, lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks, Purkinje fiber cells of the heart and lymph node. {ECO:0000269|PubMed:8769423}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.020396(Rat);0.081211(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3O2Q (X-ray 2.40A ) 3O2S (X-ray 2.50A ) 3O2T (X-ray 1.40A ) 3ODR (X-ray 2.20A ) 3ODS (X-ray 1.90A ) 4H3H (X-ray 2.20A ) 4H3K (X-ray 2.00A ) 6V4X (EM 3.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells. Colocalizes with HSF1 in nuclear stress bodies upon heat shock (PubMed:14707147). {ECO:0000269|PubMed:14707147}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |