| Gene Information | |
|---|---|
| Gene Name | ZNF856 |
| Organism | Homo sapiens (Human) |
| Gene Length | 835 |
| Protein Names | B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9H165 |
| Gene Card | BCL11A |
| Uniprot ID | Q9H165 |
| Pfam | PF00096 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. {ECO:0000269|PubMed:11161790, ECO:0000269|PubMed:11719382}.; [Isoform 1]: Expressed in fetal and adult brain, and in the plasmacytoid dendritic cell. {ECO:0000269|PubMed:16704730}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.010526(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 5VTB (X-ray 2.40A ) 6KI6 (X-ray 2.50A ) 6U9Q (X-ray 1.83A ) |
| DBSNP | rs886037864 rs886037865 rs886037866 rs886037864 rs886037865 rs886037866 rs886037864 rs886037865 rs886037866 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11161790}. Nucleus {ECO:0000269|PubMed:11161790}. Chromosome {ECO:0000269|PubMed:29606353}. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). {ECO:0000250}.; [Isoform 1]: Nucleus matrix {ECO:0000269|PubMed:16704730}. Note=Colocalizes with BCL6 in nuclear paraspeckles. {ECO:0000269|PubMed:16704730}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:27453576}. Nucleus {ECO:0000269|PubMed:27453576}. Note=Predominantly localized in the nucleus in nuclear paraspeckles. {ECO:0000269|PubMed:27453576}.; [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:27453576}. Nucleus {ECO:0000269|PubMed:27453576}. Note=Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles. {ECO:0000269|PubMed:27453576}. |
| Mouse PG classification | NA |
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