| Gene Information | |
|---|---|
| Gene Name | SARAF |
| Organism | Homo sapiens (Human) |
| Gene Length | 339 |
| Protein Names | Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000133872 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96BY9 |
| Gene Card | SARAF |
| Uniprot ID | Q96BY9 |
| Pfam | PF06682 |
| In ASD | no |
| Allosteric Prediction | no (-0.964993861) |
| Ortholog in Animals | Alpaca_ SARAF ( ortholog_one2one ) Dog_ SARAF ( ortholog_one2one ) GuineaPig_ SARAF ( ortholog_one2one ) Macaque_ SARAF ( ortholog_one2one ) Mouse_ Saraf ( ortholog_one2one ) Pig_ SARAF ( ortholog_one2one ) Rat_ Saraf ( ortholog_one2one ) Rabbit_ SARAF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in macrophages. {ECO:0000269|Ref.2}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6O2U (X-ray 1.80A ) 6O2V (X-ray 1.58A ) 6O2W (X-ray 2.10A ) |
| DBSNP | rs11538828 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:22464749}; Single-pass type I membrane protein {ECO:0000269|PubMed:22464749}. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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