| Gene Information | |
|---|---|
| Gene Name | TIE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1138 |
| Protein Names | Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) |
| Target Name | tyrosine-protein kinase receptor tie-1 |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000066056 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P35590 |
| Gene Card | TIE1 |
| Uniprot ID | P35590 |
| Pfam | PF00041; PF00047; PF07714 |
| In ASD | no |
| Allosteric Prediction | no (-0.148374482) |
| Ortholog in Animals | Alpaca_ TIE1 ( ortholog_one2one ) Dog_ TIE1 ( ortholog_one2one ) GuineaPig_ TIE1 ( ortholog_one2one ) Macaque_ TIE1 ( ortholog_one2one ) Mouse_ Tie1 ( ortholog_one2one ) Pig_ TIE1 ( ortholog_one2one ) Rat_ Tie1 ( ortholog_one2one ) Rabbit_ TIE1 ( ortholog_one2one ) |
| Ohnologs | TEK |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Specifically expressed in developing vascular endothelial cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5N06 (X-ray 2.50A ) |
| DBSNP | rs56302794 rs35573981 rs34993202 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}; Single-pass type I membrane protein {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}. |
| Mouse PG classification | NA |
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