| Gene Information | |
|---|---|
| Gene Name | KIAA1248 |
| Organism | Homo sapiens (Human) |
| Gene Length | 371 |
| Protein Names | Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UN36 |
| Gene Card | NDRG2 |
| Uniprot ID | Q9UN36 |
| Pfam | PF03096 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). {ECO:0000269|PubMed:11352569, ECO:0000269|PubMed:11936845, ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:14572661, ECO:0000269|PubMed:15207261, ECO:0000269|PubMed:15526377, ECO:0000269|PubMed:16103061}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2XMQ (X-ray 2.81A ) 2XMR (X-ray 2.00A ) 2XMS (X-ray 2.15A ) |
| DBSNP | rs36007455 rs11552412 |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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