| Gene Information | |
|---|---|
| Gene Name | RHBDF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 856 |
| Protein Names | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) |
| Target Name | inactive rhomboid protein 2 |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000129667 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6PJF5 |
| Gene Card | RHBDF2 |
| Uniprot ID | Q6PJF5 |
| Pfam | PF01694; PF12595 |
| In ASD | no |
| Allosteric Prediction | no (-1.109936454) |
| Ortholog in Animals | Alpaca_ RHBDF2 ( ortholog_one2one ) Dog_ RHBDF2 ( ortholog_one2one ) GuineaPig_ RHBDF2 ( ortholog_one2one ) Macaque_ RHBDF2 ( ortholog_one2one ) Mouse_ Rhbdf2 ( ortholog_one2one ) Pig_ RHBDF2 ( ortholog_one2one ) Rat_ Rhbdf2 ( ortholog_one2one ) Rabbit_ RHBDF2 ( ortholog_one2one ) |
| Ohnologs | RHBDF1 |
| Paralogs | PARL, RHBDL3, RHBDL1, RHBDL2, RHBDF1 |
| Tissue | NA |
| Tissue Specificity | Found in the epidermis and esophageal epithelium. {ECO:0000269|PubMed:22265016}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs387907129 rs387907130 rs3744045 rs34814954 rs11553545 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q80WQ6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80WQ6}. Cell membrane {ECO:0000269|PubMed:22265016, ECO:0000269|PubMed:29897333}. |
| Mouse PG classification | NA |
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