| Gene Information | |
|---|---|
| Gene Name | AQP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 265 |
| Protein Names | Aquaporin-5 (AQP-5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000161798 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P55064 |
| Gene Card | AQP5 |
| Uniprot ID | P55064 |
| Pfam | PF00230 |
| In ASD | no |
| Allosteric Prediction | no (-0.494948007) |
| Ortholog in Animals | Alpaca_ AQP5 ( ortholog_one2one ) Dog_ AQP2 ( ortholog_one2one ) GuineaPig_ AQP5 ( ortholog_one2one ) Macaque_ AQP5 ( ortholog_one2one ) Mouse_ Aqp5 ( ortholog_one2one ) Pig_ AQP5 ( ortholog_one2one ) Rat_ Aqp5 ( ortholog_one2one ) |
| Ohnologs | AQP4, MINDY4, MIP |
| Paralogs | MIP, AQP3, AQP1, AQP4, AQP6, AQP10, AQP8, AQP7B, AQP7, AQP9, AQP2 |
| Tissue | salivary.gland, testis |
| Tissue Specificity | Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level). {ECO:0000269|PubMed:23473857}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3D9S (X-ray 2.00A ) 5C5X (X-ray 2.60A ) 5DYE (X-ray 3.50A ) |
| DBSNP | rs398123054 rs398123055 rs398123057 rs398123056 rs368292687 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:23473857}; Multi-pass membrane protein {ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106}. Cell membrane {ECO:0000269|PubMed:23830519, ECO:0000269|PubMed:26569106, ECO:0000269|PubMed:8621489}; Multi-pass membrane protein {ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:26569106}; Multi-pass membrane protein {ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106}. Note=Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. {ECO:0000269|PubMed:26569106}. |
| Mouse PG classification | NA |
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