| Gene Information | |
|---|---|
| Gene Name | PTGES |
| Organism | Homo sapiens (Human) |
| Gene Length | 152 |
| Protein Names | Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gene 12 protein) |
| Target Name | prostaglandin e synthase |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000148344 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O14684 |
| Gene Card | PTGES |
| Uniprot ID | O14684 |
| Pfam | PF01124 |
| In ASD | yes |
| Allosteric Prediction | no (-0.999854178) |
| Ortholog in Animals | Alpaca_ PTGES ( ortholog_one2one ) Dog_ PTGES ( ortholog_one2one ) GuineaPig_ PTGES ( ortholog_one2one ) Macaque_ PTGES ( ortholog_one2one ) Mouse_ Ptges ( ortholog_one2one ) Pig_ PTGES ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MGST1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3DWW (EM 3.50A ) 4AL0 (X-ray 1.16A ) 4AL1 (X-ray 1.95A ) 4BPM (X-ray 2.08A ) 4WAB (X-ray 2.70A ) 4YK5 (X-ray 1.42A ) 4YL0 (X-ray 1.52A ) 4YL1 (X-ray 1.41A ) 4YL3 (X-ray 1.41A ) 5BQG (X-ray 1.44A ) 5BQH (X-ray 1.60A ) 5BQI (X-ray 1.88A ) 5K0I (X-ray 1.30A ) 5T36 (X-ray 1.40A ) 5T37 (X-ray 1.76A ) 5TL9 (X-ray 1.20A ) 6VL4 (X-ray 1.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:10377395, ECO:0000269|PubMed:16439136, ECO:0000269|PubMed:18682561, ECO:0000269|PubMed:27684486}; Multi-pass membrane protein {ECO:0000303|PubMed:18682561}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10869354}. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. {ECO:0000269|PubMed:10869354}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |