| Gene Information | |
|---|---|
| Gene Name | SIGLEC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 551 |
| Protein Names | Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000105501 ) 544 ( ENSG00000268500 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O15389 |
| Gene Card | SIGLEC5 |
| Uniprot ID | O15389 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.759760967) |
| Ortholog in Animals | Alpaca_ SIGLEC5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAG, SIGLECL1, CD22, SIGLEC14, SIGLEC7, SIGLEC8, CD33, SIGLEC9, SIGLEC12, SIGLEC6, SIGLEC11, SIGLEC16, SIGLEC10, SIGLEC1, SIGLEC15, TMEM25 |
| Tissue | appendix, bone.marrow, spleen, whole.blood |
| Tissue Specificity | Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ZG1 (X-ray 2.70A ) 2ZG2 (X-ray 2.85A ) 2ZG3 (X-ray 3.00A ) |
| DBSNP | rs1973019 rs1807124 rs2278831 rs8108074 rs3829655 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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