| Gene Information | |
|---|---|
| Gene Name | FYCO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1478 |
| Protein Names | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000163820 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BQS8 |
| Gene Card | FYCO1 |
| Uniprot ID | Q9BQS8 |
| Pfam | PF01363; PF02759 |
| In ASD | no |
| Allosteric Prediction | no (-1.069627104) |
| Ortholog in Animals | Alpaca_ FYCO1 ( ortholog_one2one ) Dog_ FYCO1 ( ortholog_one2one ) GuineaPig_ FYCO1 ( ortholog_one2one ) Macaque_ FYCO1 ( ortholog_one2one ) Mouse_ Fyco1 ( ortholog_one2one ) Rat_ Fyco1 ( ortholog_one2one ) Rabbit_ FYCO1 ( ortholog_one2one ) |
| Ohnologs | RUFY4 |
| Paralogs | RUFY4 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart and skeletal muscle. {ECO:0000269|PubMed:11896456}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5CX3 (X-ray 2.30A ) 5D94 (X-ray 1.53A ) 7BQI (X-ray 1.30A ) |
| DBSNP | rs4683158 rs9875356 rs3733100 rs3733101 rs33910087 rs3796375 rs34801630 rs13059238 rs387906965 |
| Subcellular location [CC] | Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes. |
| Mouse PG classification | NA |
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