| Gene Information | |
|---|---|
| Gene Name | CTAG1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 180 |
| Protein Names | Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2) |
| Target Name | cancer/testis antigen 1 |
| Target Type | Clinical trial target |
| Gene Age | 36 ( ENSG00000268651 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P78358 |
| Gene Card | CTAG1A;CTAG1B |
| Uniprot ID | P78358 |
| Pfam | PF09341 |
| In ASD | no |
| Allosteric Prediction | no (-1.152412002) |
| Ortholog in Animals | Mouse_ Ctag2l2 ( ortholog_many2many ) Mouse_ Ctag2 ( ortholog_many2many ) Mouse_ Ctag2l1 ( ortholog_many2many ) Rat_ Ctag2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | CTAG1B, CTAG2, LAGE3 |
| Tissue | NA |
| Tissue Specificity | Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level). {ECO:0000269|PubMed:12065688}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1S9W (X-ray 2.20A ) 2BNQ (X-ray 1.70A ) 2BNR (X-ray 1.90A ) 2F53 (X-ray 2.10A ) 2F54 (X-ray 2.70A ) 2P5E (X-ray 1.89A ) 2P5W (X-ray 2.20A ) 2PYE (X-ray 2.30A ) 3GJF (X-ray 1.90A ) 3HAE (X-ray 2.90A ) 3KLA (X-ray 1.65A ) 6AT5 (X-ray 1.50A ) 6AVF (X-ray 2.03A ) 6AVG (X-ray 2.60A ) 6RP9 (X-ray 3.12A ) 6RPA (X-ray 2.56A ) 6RPB (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12065688}. |
| Mouse PG classification | NA |
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