| Gene Information | |
|---|---|
| Gene Name | HSPG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4391 |
| Protein Names | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] |
| Target Name | perlecan |
| Target Type | Discontinued target |
| Gene Age | 987 ( ENSG00000142798 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | HSPG2 |
| Uniprot ID | P98160 |
| Pfam | PF00008; PF07679; PF00052; PF00053; PF00054; PF00057 |
| In ASD | no |
| Allosteric Prediction | yes (0.181823567) |
| Ortholog in Animals | Alpaca_ HSPG2 ( ortholog_one2one ) Dog_ HSPG2 ( ortholog_one2one ) GuineaPig_ HSPG2 ( ortholog_one2one ) Macaque_ HSPG2 ( ortholog_one2one ) Mouse_ Hspg2 ( ortholog_one2one ) Pig_ HSPG2 ( ortholog_one2one ) Rat_ AABR07073181.1 ( ortholog_one2one ) Rabbit_ HSPG2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LAMB2, LAMC3, NTN4, LAMB1, LAMA3, LAMC1, ATRNL1, LAMA2, TMEFF2, ATRN, NTN1, NTN3, LAMC2, TMEFF1, LAMA1, AGRN, LAMB4, NTNG2, NTNG1, LAMA4, MEGF9, MEGF8, LAMB3, EGFLAM, LAMA5, NTN5, USH2A |
| Tissue | NA |
| Tissue Specificity | Found in the basement membranes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3SH4 (X-ray 1.50A ) 3SH5 (X-ray 2.80A ) |
| DBSNP | rs1869780 rs17460381 rs1874792 rs989994 rs2229481 rs10917058 rs897471 rs137853248 rs2229483 rs2229474 rs2229475 rs2229489 rs2229490 rs2229491 rs2228349 rs2291827 rs2270699 rs2229493 rs17459097 rs3736360 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |