| Gene Information | |
|---|---|
| Gene Name | DHX58 |
| Organism | Homo sapiens (Human) |
| Gene Length | 678 |
| Protein Names | ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000108771 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q96C10 |
| Gene Card | DHX58 |
| Uniprot ID | Q96C10 |
| Pfam | PF00271; PF04851; PF18119; PF11648 |
| In ASD | no |
| Allosteric Prediction | no (-0.617704963) |
| Ortholog in Animals | Alpaca_ DHX58 ( ortholog_one2one ) Dog_ DHX58 ( ortholog_one2one ) GuineaPig_ DHX58 ( ortholog_one2one ) Macaque_ DHX58 ( ortholog_one2one ) Mouse_ Dhx58 ( ortholog_one2one ) Pig_ DHX58 ( ortholog_one2one ) Rat_ Dhx58 ( ortholog_one2one ) Rabbit_ DHX58 ( ortholog_one2one ) |
| Ohnologs | IFIH1 |
| Paralogs | IFIH1, DDX58 |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, nerve and spleen. Also expressed in the brain. {ECO:0000269|PubMed:31256877}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2RQA (NMR - ) 2W4R (X-ray 2.60A ) 3EQT (X-ray 2.00A ) |
| DBSNP | rs200502586 rs34891485 rs35118457 rs2074158 rs2074160 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19380577}. |
| Mouse PG classification | NA |
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