| Gene Information | |
|---|---|
| Gene Name | ZNF451 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1061 |
| Protein Names | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000112200 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y4E5 |
| Gene Card | ZNF451 |
| Uniprot ID | Q9Y4E5 |
| Pfam | PF18479 |
| In ASD | no |
| Allosteric Prediction | no (-0.056427445) |
| Ortholog in Animals | Alpaca_ ZNF451 ( ortholog_one2one ) Dog_ ZNF451 ( ortholog_one2one ) GuineaPig_ ZNF451 ( ortholog_one2one ) Macaque_ ZNF451 ( ortholog_one2one ) Mouse_ Zfp451 ( ortholog_one2one ) Pig_ ZNF451 ( ortholog_one2one ) Rat_ Zfp451 ( ortholog_one2one ) Rabbit_ ZNF451 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ZNF575, ZNF276, HIC1, ZNF653, ZNF362, ZNF410, PATZ1, MTF1, PRDM1, HIC2, ZNF76, ZFP91, PRDM6, ZNF296, ZBTB1, SNAI3, SNAI2, ZBTB20, ZNF281, MAZ, ZBTB18, ZNF143, ZBTB16, SNAI1, ZNF148, ZBTB32, ZBTB45, ZBTB7C, ZBTB42, ZNF692, PRDM14, VEZF1, SCRT2, SCRT1, ZNF384, PRDM10 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5D2M (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267}. Nucleus, PML body {ECO:0000269|PubMed:18656483}. Nucleus, nucleoplasm. Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location. {ECO:0000269|PubMed:18656483}. |
| Mouse PG classification | NA |
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