| Gene Information | |
|---|---|
| Gene Name | TENM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2774 |
| Protein Names | Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000145934 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | NA |
| Gene Card | TENM2 |
| Uniprot ID | Q9NT68 |
| Pfam | PF06484; PF15636 |
| In ASD | no |
| Allosteric Prediction | no (-1.232373953) |
| Ortholog in Animals | Alpaca_ TENM2 ( ortholog_one2one ) Dog_ TENM2 ( ortholog_one2one ) GuineaPig_ TENM2 ( ortholog_one2one ) Macaque_ TENM2 ( ortholog_one2one ) Mouse_ Tenm2 ( ortholog_one2one ) Pig_ TENM2 ( ortholog_one2one ) Rat_ Tenm2 ( ortholog_one2one ) Rabbit_ TENM2 ( ortholog_one2one ) |
| Ohnologs | TENM1, TENM4, TENM3 |
| Paralogs | TENM3, TENM4, TENM1, NAGPA |
| Tissue | heart |
| Tissue Specificity | Highly expressed in heart, followed by brain, liver, kidney and fetal brain and weakly expressed in lung and testis. No expression was detected in skeletal muscle, pancreas, spleen, ovary and fetal liver. {ECO:0000269|PubMed:10574461}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6CMX (EM 3.10A ) 6VHH (EM 2.97A ) |
| DBSNP | rs6862925 rs11957063 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Colocalizes with ADGRL1 across intercellular junctions. {ECO:0000250}.; [Isoform 2]: Cell membrane. Note=Colocalizes with ADGRL1 across intercellular junctions.; [Ten-2 intracellular domain]: Nucleus, PML body {ECO:0000250}. |
| Mouse PG classification | NA |
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