Gene Information
Gene NameDUSP26
OrganismHomo sapiens (Human)
Gene Length211
Protein NamesDual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP3) (Low-molecular-mass dual-specificity phosphatase 4) (DSP-4) (LDP-4) (Mitogen-activated protein kinase phosphatase 8) (MAP kinase phosphatase 8) (MKP-8) (Novel amplified gene in thyroid anaplastic cancer)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000133878 )
Evolutionary StageEukaryota
AlphaFoldDBQ9BV47
Gene CardDUSP26
Uniprot IDQ9BV47
PfamPF00782
In ASDno
Allosteric Predictionno (-0.06870014)
Ortholog in AnimalsAlpaca_ DUSP26 ( ortholog_one2one )
Dog_ DUSP26 ( ortholog_one2one )
GuineaPig_ DUSP26 ( ortholog_one2one )
Macaque_ DUSP26 ( ortholog_one2one )
Mouse_ Dusp26 ( ortholog_one2one )
Pig_ DUSP26 ( ortholog_one2one )
Rat_ Dusp26 ( ortholog_one2one )
OhnologsDUSP13, DUSP29
ParalogsDUSP6, DUSP4, DUSP12, DUSP10, STYXL2, SSH3, DUSP19, DUSP1, KASH5, SSH1, DUSP29, DUSP16, DUSP21, DUSP2, DUSP8, DUSP13, EPM2A, DUSP7, STYX, SSH2, PTPMT1, DUSP22, DUSP18, DUSP15, DUSP14, DUSP28, STYXL1, DUSP5, DUSP9, DUSP3
Tissueskeletal.muscle, artery, cerebellum, left.ventricle
Tissue SpecificityBrain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. {ECO:0000269|PubMed:15796912, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:16924234, ECO:0000269|PubMed:17001450}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2E0T  (X-ray  1.67A  )  4B04  (X-ray  2.20A  )  4HRF  (X-ray  1.68A  )  5GTJ  (X-ray  2.00A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm. Nucleus. Golgi apparatus.
Mouse PG classificationNA
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