| Gene Information | |
|---|---|
| Gene Name | MAST1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1538 |
| Protein Names | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) |
| Target Name | microtubule-associated serine/threonine-protein kinase 1 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000105613 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z460 |
| Gene Card | CLASP1 |
| Uniprot ID | Q7Z460 |
| Pfam | PF12348 |
| In ASD | no |
| Allosteric Prediction | no (-0.004490265) |
| Ortholog in Animals | Alpaca_ MAST1 ( ortholog_one2one ) Dog_ MAST1 ( ortholog_one2one ) GuineaPig_ MAST1 ( ortholog_one2one ) Macaque_ MAST1 ( ortholog_one2one ) Mouse_ Mast1 ( ortholog_one2one ) Pig_ MAST1 ( ortholog_one2one ) Rat_ MAST1 ( ortholog_one2one ) |
| Ohnologs | MAST4, MAST2, MAST3 |
| Paralogs | STK32B, MAST3, STK32A, MAST2, LATS2, SGK1, MAST4, SGK2, SGK3, LATS1, STK32C, DMPK, MASTL |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4K92 (X-ray 2.00A ) 6MQ5 (X-ray 2.15A ) 6MQ7 (X-ray 1.78A ) |
| DBSNP | rs17761055 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network {ECO:0000305}. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. |
| Mouse PG classification | NA |
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