| Gene Information | |
|---|---|
| Gene Name | FOSB |
| Organism | Homo sapiens (Human) |
| Gene Length | 338 |
| Protein Names | Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000125740 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P53539 |
| Gene Card | FOSB |
| Uniprot ID | P53539 |
| Pfam | PF00170 |
| In ASD | no |
| Allosteric Prediction | no (-0.052552562) |
| Ortholog in Animals | Alpaca_ FOSB ( ortholog_one2one ) Dog_ FOSB ( ortholog_one2one ) GuineaPig_ FOSB ( ortholog_one2one ) Macaque_ FOSB ( ortholog_one2one ) Mouse_ Fosb ( ortholog_one2one ) Pig_ FOSB ( ortholog_one2one ) Rat_ Fosb ( ortholog_one2one ) Rabbit_ FOSB ( ortholog_one2one ) |
| Ohnologs | FOSL2, FOS, FOSL1 |
| Paralogs | BATF, FOSL1, FOSL2, JDP2, ATF3, FOS, BATF3, BATF2 |
| Tissue | adipose.tissue, ovary |
| Tissue Specificity | [Isoform 11]: Expressed in the nucleus accumbens of the striatum (at protein level). {ECO:0000269|PubMed:20473292}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5VPA (X-ray 2.83A ) 5VPB (X-ray 2.69A ) 5VPC (X-ray 2.50A ) 5VPD (X-ray 2.79A ) 5VPE (X-ray 2.05A ) 5VPF (X-ray 2.69A ) 6UCI (X-ray 2.09A ) 6UCL (X-ray 2.21A ) 6UCM (X-ray 2.42A ) |
| DBSNP | rs28381241 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:P13346}. |
| Mouse PG classification | NA |
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