| Gene Information | |
|---|---|
| Gene Name | MS4A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 297 |
| Protein Names | B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) |
| Target Name | b-lymphocyte antigen cd20 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000156738 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P11836 |
| Gene Card | MS4A1 |
| Uniprot ID | P11836 |
| Pfam | PF04103 |
| In ASD | no |
| Allosteric Prediction | no (-0.544412722) |
| Ortholog in Animals | Alpaca_ MS4A1 ( ortholog_one2one ) Dog_ MS4A1 ( ortholog_one2one ) GuineaPig_ MS4A1 ( ortholog_one2one ) Macaque_ MS4A1 ( ortholog_one2one ) Mouse_ Ms4a1 ( ortholog_one2one ) Pig_ MS4A1 ( ortholog_one2one ) Rat_ Ms4a1 ( ortholog_one2one ) Rabbit_ MS4A1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MS4A12, MS4A6E, MS4A6A, MS4A7, MS4A10, MS4A2, MS4A8, MS4A15, TMEM212, MS4A13, MS4A5, MS4A18, MS4A4E, MS4A4A, MS4A3, MS4A14 |
| Tissue | lymph.node, spleen, tonsil, appendix |
| Tissue Specificity | Expressed on B-cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2OSL (X-ray 2.60A ) 3BKY (X-ray 2.61A ) 3PP4 (X-ray 1.60A ) 6VJA (EM 3.30A ) 6Y90 (EM 3.69A ) 6Y92 (EM 4.73A ) 6Y97 (EM 4.33A ) 6Y9A (EM 4.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:22615937}; Multi-pass membrane protein {ECO:0000269|PubMed:22615937}. Cell membrane {ECO:0000269|PubMed:22615937}; Lipid-anchor {ECO:0000269|PubMed:22615937}. Note=Constitutively associated with membrane rafts. {ECO:0000269|PubMed:12920111}. |
| Mouse PG classification | NA |
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