Gene Information

Gene Information
Gene Name	CDK2
Organism	Homo sapiens (Human)
Gene Length	298
Protein Names	Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Target Name	cyclin-dependent kinase 2
Target Type	Clinical trial target
Gene Age	645 ( ENSG00000123374 )
Evolutionary Stage	Eukaryota
AlphaFoldDB	P24941
Gene Card	CDK2
Uniprot ID	P24941
Pfam	PF00069
In ASD	yes
Allosteric Prediction	yes (1.115308786)
Ortholog in Animals	Alpaca_ CDK2 ( ortholog_one2one ) Dog_ CDK2 ( ortholog_one2one ) GuineaPig_ CDK2 ( ortholog_one2one ) Mouse_ Cdk2 ( ortholog_one2one ) Pig_ CDK2 ( ortholog_one2one ) Rat_ Cdk2 ( ortholog_one2one ) Rabbit_ CDK2 ( ortholog_one2one )
Ohnologs	NA
Paralogs	CDK14, CDKL2, CDK5, CDKL3, CDK7, CDK3, CDK1, CDKL1, CDK19, CDKL5, CDK6, CDK16, CDK15, CDK4, CDKL4, CDK20, CDK9, CDK12, CDK8, CDK10, CDK11B, CDK11A, CDK13, CDK18, CDK17, PRPF4B
Tissue	NA
Tissue Specificity	NA
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1AQ1 (X-ray 2.00A ) 1B38 (X-ray 2.00A ) 1B39 (X-ray 2.10A ) 1BUH (X-ray 2.60A ) 1CKP (X-ray 2.05A ) 1DI8 (X-ray 2.20A ) 1DM2 (X-ray 2.10A ) 1E1V (X-ray 1.95A ) 1E1X (X-ray 1.85A ) 1E9H (X-ray 2.50A ) 1F5Q (X-ray 2.50A ) 1FIN (X-ray 2.30A ) 1FQ1 (X-ray 3.00A ) 1FVT (X-ray 2.20A ) 1FVV (X-ray 2.80A ) 1G5S (X-ray 2.61A ) 1GIH (X-ray 2.80A ) 1GII (X-ray 2.00A ) 1GIJ (X-ray 2.20A ) 1GY3 (X-ray 2.70A ) 1GZ8 (X-ray 1.30A ) 1H00 (X-ray 1.60A ) 1H01 (X-ray 1.79A ) 1H07 (X-ray 1.85A ) 1H08 (X-ray 1.80A ) 1H0V (X-ray 1.90A ) 1H0W (X-ray 2.10A ) 1H1P (X-ray 2.10A ) 1H1Q (X-ray 2.50A ) 1H1R (X-ray 2.00A ) 1H1S (X-ray 2.00A ) 1H24 (X-ray 2.50A ) 1H25 (X-ray 2.50A ) 1H26 (X-ray 2.24A ) 1H27 (X-ray 2.20A ) 1H28 (X-ray 2.80A ) 1HCK (X-ray 1.90A ) 1HCL (X-ray 1.80A ) 1JST (X-ray 2.60A ) 1JSU (X-ray 2.30A ) 1JSV (X-ray 1.96A ) 1JVP (X-ray 1.53A ) 1KE5 (X-ray 2.20A ) 1KE6 (X-ray 2.00A ) 1KE7 (X-ray 2.00A ) 1KE8 (X-ray 2.00A ) 1KE9 (X-ray 2.00A ) 1OGU (X-ray 2.60A ) 1OI9 (X-ray 2.10A ) 1OIQ (X-ray 2.31A ) 1OIR (X-ray 1.91A ) 1OIT (X-ray 1.60A ) 1OIU (X-ray 2.00A ) 1OIY (X-ray 2.40A ) 1OKV (X-ray 2.40A ) 1OKW (X-ray 2.50A ) 1OL1 (X-ray 2.90A ) 1OL2 (X-ray 2.60A ) 1P2A (X-ray 2.50A ) 1P5E (X-ray 2.22A ) 1PF8 (X-ray 2.51A ) 1PKD (X-ray 2.30A ) 1PW2 (X-ray 1.95A ) 1PXI (X-ray 1.95A ) 1PXJ (X-ray 2.30A ) 1PXK (X-ray 2.80A ) 1PXL (X-ray 2.50A ) 1PXM (X-ray 2.53A ) 1PXN (X-ray 2.50A ) 1PXO (X-ray 1.96A ) 1PXP (X-ray 2.30A ) 1PYE (X-ray 2.00A ) 1QMZ (X-ray 2.20A ) 1R78 (X-ray 2.00A ) 1URC (X-ray 2.60A ) 1URW (X-ray 1.60A ) 1V1K (X-ray 2.31A ) 1VYW (X-ray 2.30A ) 1VYZ (X-ray 2.21A ) 1W0X (X-ray 2.20A ) 1W8C (X-ray 2.05A ) 1W98 (X-ray 2.15A ) 1WCC (X-ray 2.20A ) 1Y8Y (X-ray 2.00A ) 1Y91 (X-ray 2.15A ) 1YKR (X-ray 1.80A ) 2A0C (X-ray 1.95A ) 2A4L (X-ray 2.40A ) 2B52 (X-ray 1.88A ) 2B53 (X-ray 2.00A ) 2B54 (X-ray 1.85A ) 2B55 (X-ray 1.85A ) 2BHE (X-ray 1.90A ) 2BHH (X-ray 2.60A ) 2BKZ (X-ray 2.60A ) 2BPM (X-ray 2.40A ) 2BTR (X-ray 1.85A ) 2BTS (X-ray 1.99A ) 2C4G (X-ray 2.70A ) 2C5N (X-ray 2.10A ) 2C5O (X-ray 2.10A ) 2C5V (X-ray 2.90A ) 2C5X (X-ray 2.90A ) 2C5Y (X-ray 2.25A ) 2C68 (X-ray 1.95A ) 2C69 (X-ray 2.10A ) 2C6I (X-ray 1.80A ) 2C6K (X-ray 1.90A ) 2C6L (X-ray 2.30A ) 2C6M (X-ray 1.90A ) 2C6O (X-ray 2.10A ) 2C6T (X-ray 2.61A ) 2CCH (X-ray 1.70A ) 2CCI (X-ray 2.70A ) 2CJM (X-ray 2.30A ) 2CLX (X-ray 1.80A ) 2DS1 (X-ray 2.00A ) 2DUV (X-ray 2.20A ) 2EXM (X-ray 1.80A ) 2FVD (X-ray 1.85A ) 2G9X (X-ray 2.50A ) 2I40 (X-ray 2.80A ) 2IW6 (X-ray 2.30A ) 2IW8 (X-ray 2.30A ) 2IW9 (X-ray 2.00A ) 2J9M (X-ray 2.50A ) 2JGZ (X-ray 2.90A ) 2R3F (X-ray 1.50A ) 2R3G (X-ray 1.55A ) 2R3H (X-ray 1.50A ) 2R3I (X-ray 1.28A ) 2R3J (X-ray 1.65A ) 2R3K (X-ray 1.70A ) 2R3L (X-ray 1.65A ) 2R3M (X-ray 1.70A ) 2R3N (X-ray 1.63A ) 2R3O (X-ray 1.80A ) 2R3P (X-ray 1.66A ) 2R3Q (X-ray 1.35A ) 2R3R (X-ray 1.47A ) 2R64 (X-ray 2.30A ) 2UUE (X-ray 2.06A ) 2UZB (X-ray 2.70A ) 2UZD (X-ray 2.72A ) 2UZE (X-ray 2.40A ) 2UZL (X-ray 2.40A ) 2UZN (X-ray 2.30A ) 2UZO (X-ray 2.30A ) 2V0D (X-ray 2.20A ) 2V22 (X-ray 2.60A ) 2VTA (X-ray 2.00A ) 2VTH (X-ray 1.90A ) 2VTI (X-ray 2.00A ) 2VTJ (X-ray 2.20A ) 2VTL (X-ray 2.00A ) 2VTM (X-ray 2.25A ) 2VTN (X-ray 2.20A ) 2VTO (X-ray 2.19A ) 2VTP (X-ray 2.15A ) 2VTQ (X-ray 1.90A ) 2VTR (X-ray 1.90A ) 2VTS (X-ray 1.90A ) 2VTT (X-ray 1.68A ) 2VU3 (X-ray 1.85A ) 2VV9 (X-ray 1.90A ) 2W05 (X-ray 1.90A ) 2W06 (X-ray 2.04A ) 2W17 (X-ray 2.15A ) 2W1H (X-ray 2.15A ) 2WEV (X-ray 2.30A ) 2WFY (X-ray 2.53A ) 2WHB (X-ray 2.90A ) 2WIH (X-ray 2.50A ) 2WIP (X-ray 2.80A ) 2WMA (X-ray 2.80A ) 2WMB (X-ray 2.60A ) 2WPA (X-ray 2.51A ) 2WXV (X-ray 2.60A ) 2X1N (X-ray 2.75A ) 2XMY (X-ray 1.90A ) 2XNB (X-ray 1.85A ) 3BHT (X-ray 2.00A ) 3BHU (X-ray 2.30A ) 3BHV (X-ray 2.10A ) 3DDP (X-ray 2.70A ) 3DDQ (X-ray 1.80A ) 3DOG (X-ray 2.70A ) 3EID (X-ray 3.15A ) 3EJ1 (X-ray 3.22A ) 3EOC (X-ray 3.20A ) 3EZR (X-ray 1.90A ) 3EZV (X-ray 1.99A ) 3F5X (X-ray 2.40A ) 3FZ1 (X-ray 1.90A ) 3IG7 (X-ray 1.80A ) 3IGG (X-ray 1.80A ) 3LE6 (X-ray 2.00A ) 3LFN (X-ray 2.28A ) 3LFQ (X-ray 2.03A ) 3LFS (X-ray 2.40A ) 3MY5 (X-ray 2.10A ) 3NS9 (X-ray 1.78A ) 3PJ8 (X-ray 1.96A ) 3PXF (X-ray 1.80A ) 3PXQ (X-ray 1.90A ) 3PXR (X-ray 2.00A ) 3PXY (X-ray 1.80A ) 3PXZ (X-ray 1.70A ) 3PY0 (X-ray 1.75A ) 3PY1 (X-ray 2.05A ) 3QHR (X-ray 2.17A ) 3QHW (X-ray 1.91A ) 3QL8 (X-ray 1.90A ) 3QQF (X-ray 1.75A ) 3QQG (X-ray 1.90A ) 3QQH (X-ray 1.87A ) 3QQJ (X-ray 1.70A ) 3QQK (X-ray 1.86A ) 3QQL (X-ray 1.85A ) 3QRT (X-ray 1.75A ) 3QRU (X-ray 1.95A ) 3QTQ (X-ray 1.80A ) 3QTR (X-ray 1.85A ) 3QTS (X-ray 1.90A ) 3QTU (X-ray 1.82A ) 3QTW (X-ray 1.85A ) 3QTX (X-ray 1.95A ) 3QTZ (X-ray 2.00A ) 3QU0 (X-ray 1.95A ) 3QWJ (X-ray 1.75A ) 3QWK (X-ray 1.85A ) 3QX2 (X-ray 1.75A ) 3QX4 (X-ray 1.92A ) 3QXO (X-ray 1.75A ) 3QXP (X-ray 1.75A ) 3QZF (X-ray 2.00A ) 3QZG (X-ray 1.75A ) 3QZH (X-ray 1.95A ) 3QZI (X-ray 1.75A ) 3R1Q (X-ray 1.85A ) 3R1S (X-ray 1.80A ) 3R1Y (X-ray 1.80A ) 3R28 (X-ray 1.75A ) 3R6X (X-ray 1.75A ) 3R71 (X-ray 1.75A ) 3R73 (X-ray 1.70A ) 3R7E (X-ray 1.90A ) 3R7I (X-ray 1.85A ) 3R7U (X-ray 1.75A ) 3R7V (X-ray 1.95A ) 3R7Y (X-ray 1.90A ) 3R83 (X-ray 1.75A ) 3R8L (X-ray 1.90A ) 3R8M (X-ray 1.80A ) 3R8P (X-ray 1.80A ) 3R8U (X-ray 2.00A ) 3R8V (X-ray 1.90A ) 3R8Z (X-ray 1.85A ) 3R9D (X-ray 1.95A ) 3R9H (X-ray 2.10A ) 3R9N (X-ray 1.75A ) 3R9O (X-ray 1.90A ) 3RAH (X-ray 1.75A ) 3RAI (X-ray 1.70A ) 3RAK (X-ray 1.75A ) 3RAL (X-ray 1.75A ) 3RJC (X-ray 1.85A ) 3RK5 (X-ray 2.00A ) 3RK7 (X-ray 1.80A ) 3RK9 (X-ray 1.85A ) 3RKB (X-ray 2.00A ) 3RM6 (X-ray 1.60A ) 3RM7 (X-ray 1.85A ) 3RMF (X-ray 1.75A ) 3RNI (X-ray 1.95A ) 3ROY (X-ray 1.75A ) 3RPO (X-ray 1.75A ) 3RPR (X-ray 1.75A ) 3RPV (X-ray 1.80A ) 3RPY (X-ray 1.90A ) 3RZB (X-ray 1.90A ) 3S00 (X-ray 1.80A ) 3S0O (X-ray 2.00A ) 3S1H (X-ray 1.75A ) 3S2P (X-ray 2.30A ) 3SQQ (X-ray 1.85A ) 3SW4 (X-ray 1.70A ) 3SW7 (X-ray 1.80A ) 3TI1 (X-ray 1.99A ) 3TIY (X-ray 1.84A ) 3TIZ (X-ray 2.02A ) 3TNW (X-ray 2.00A ) 3ULI (X-ray 2.00A ) 3UNJ (X-ray 1.90A ) 3UNK (X-ray 2.10A ) 3WBL (X-ray 2.00A ) 4ACM (X-ray 1.63A ) 4BCK (X-ray 2.05A ) 4BCM (X-ray 2.45A ) 4BCN (X-ray 2.10A ) 4BCO (X-ray 2.05A ) 4BCP (X-ray 2.26A ) 4BCQ (X-ray 2.40A ) 4BGH (X-ray 1.95A ) 4BZD (X-ray 1.83A ) 4CFM (X-ray 2.85A ) 4CFN (X-ray 2.20A ) 4CFU (X-ray 2.20A ) 4CFV (X-ray 2.00A ) 4CFW (X-ray 2.45A ) 4CFX (X-ray 3.50A ) 4D1X (X-ray 2.10A ) 4D1Z (X-ray 1.85A ) 4EK3 (X-ray 1.34A ) 4EK4 (X-ray 1.26A ) 4EK5 (X-ray 1.60A ) 4EK6 (X-ray 1.52A ) 4EK8 (X-ray 1.70A ) 4EOI (X-ray 2.00A ) 4EOJ (X-ray 1.65A ) 4EOK (X-ray 2.57A ) 4EOL (X-ray 2.40A ) 4EOM (X-ray 2.10A ) 4EON (X-ray 2.40A ) 4EOO (X-ray 2.10A ) 4EOP (X-ray 1.99A ) 4EOQ (X-ray 2.15A ) 4EOR (X-ray 2.20A ) 4EOS (X-ray 2.57A ) 4ERW (X-ray 2.00A ) 4EZ3 (X-ray 2.00A ) 4EZ7 (X-ray 2.49A ) 4FKG (X-ray 1.51A ) 4FKI (X-ray 1.60A ) 4FKJ (X-ray 1.63A ) 4FKL (X-ray 1.26A ) 4FKO (X-ray 1.55A ) 4FKP (X-ray 1.60A ) 4FKQ (X-ray 1.75A ) 4FKR (X-ray 1.90A ) 4FKS (X-ray 1.55A ) 4FKT (X-ray 1.60A ) 4FKU (X-ray 1.47A ) 4FKV (X-ray 1.70A ) 4FKW (X-ray 1.80A ) 4FX3 (X-ray 2.75A ) 4GCJ (X-ray 1.42A ) 4I3Z (X-ray 2.05A ) 4II5 (X-ray 2.15A ) 4KD1 (X-ray 1.70A ) 4LYN (X-ray 2.00A ) 4NJ3 (X-ray 1.85A ) 4RJ3 (X-ray 1.63A ) 5A14 (X-ray 2.00A ) 5AND (X-ray 2.30A ) 5ANE (X-ray 1.70A ) 5ANG (X-ray 1.90A ) 5ANI (X-ray 1.90A ) 5ANJ (X-ray 1.60A ) 5ANK (X-ray 1.90A ) 5ANO (X-ray 1.70A ) 5CYI (X-ray 2.00A ) 5D1J (X-ray 1.80A ) 5FP5 (X-ray 2.16A ) 5FP6 (X-ray 1.85A ) 5IEV (X-ray 2.03A ) 5IEX (X-ray 2.03A ) 5IEY (X-ray 1.66A ) 5IF1 (X-ray 2.61A ) 5JQ5 (X-ray 1.94A ) 5JQ8 (X-ray 1.94A ) 5K4J (X-ray 1.60A ) 5L2W (X-ray 2.80A ) 5LMK (X-ray 2.40A ) 5MHQ (X-ray 1.30A ) 5NEV (X-ray 2.97A ) 5OO0 (X-ray 1.60A ) 5OO1 (X-ray 2.00A ) 5OO3 (X-ray 1.73A ) 5OSJ (X-ray 1.83A ) 5OSM (X-ray 1.77A ) 5UQ1 (X-ray 3.20A ) 5UQ2 (X-ray 2.70A ) 5UQ3 (X-ray 3.60A ) 6ATH (X-ray 1.82A ) 6GUB (X-ray 2.52A ) 6GUC (X-ray 2.00A ) 6GUE (X-ray 1.99A ) 6GUF (X-ray 2.65A ) 6GUH (X-ray 1.50A ) 6GUK (X-ray 1.30A ) 6GVA (X-ray 2.15A ) 6INL (X-ray 1.75A ) 6JGM (X-ray 2.30A ) 6OQI (X-ray 2.00A ) 6P3W (X-ray 2.54A ) 6Q3B (X-ray 1.11A ) 6Q3C (X-ray 1.29A ) 6Q3F (X-ray 1.18A ) 6Q48 (X-ray 1.03A ) 6Q49 (X-ray 1.00A ) 6Q4A (X-ray 1.13A ) 6Q4B (X-ray 1.12A ) 6Q4C (X-ray 1.73A ) 6Q4D (X-ray 1.07A ) 6Q4E (X-ray 1.06A ) 6Q4F (X-ray 1.21A ) 6Q4G (X-ray 0.98A ) 6Q4H (X-ray 1.00A ) 6Q4I (X-ray 1.11A ) 6Q4J (X-ray 1.05A ) 6Q4K (X-ray 1.06A ) 6RIJ (X-ray 2.20A ) 6SG4 (X-ray 2.43A ) 6YL1 (X-ray 1.66A ) 6YL6 (X-ray 1.70A ) 6YLK (X-ray 1.65A ) 7ACK (X-ray 1.80A ) 7B5L (EM 3.80A ) 7B5R (EM 3.80A ) 7B7S (X-ray 2.54A ) 7E34 (X-ray 3.19A ) 7KJS (X-ray 2.19A ) 7M2F (X-ray 1.63A ) 7NVQ (X-ray 2.05A ) 7QHL (X-ray 1.70A ) 7RA5 (X-ray 1.67A ) 7RWE (X-ray 1.59A ) 7RWF (X-ray 1.50A ) 7RXO (X-ray 1.38A ) 7VDU (X-ray 1.53A )
DBSNP	rs3087335 rs11554376 rs2069413
Subcellular location [CC]	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).
Mouse PG classification	NA
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