| Gene Information | |
|---|---|
| Gene Name | ZIZ3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2186 |
| Protein Names | Dedicator of cytokinesis protein 10 (Zizimin-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96BY6 |
| Gene Card | DOCK10 |
| Uniprot ID | Q96BY6 |
| Pfam | PF06920; PF20422; PF20421; PF14429; PF11878; PF00169 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells. {ECO:0000269|PubMed:18499258, ECO:0000269|PubMed:21514340, ECO:0000269|PubMed:9734811}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6TKY (X-ray 2.55A ) 6TKZ (X-ray 2.64A ) 6TM1 (X-ray 3.71A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:18499258}. Cytoplasm {ECO:0000269|PubMed:18499258}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q8BZN6}. |
| Mouse PG classification | NA |
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