| Gene Information | |
|---|---|
| Gene Name | CRTAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 393 |
| Protein Names | Cytotoxic and regulatory T-cell molecule (Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000109943 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95727 |
| Gene Card | CRTAM |
| Uniprot ID | O95727 |
| Pfam | PF08205; PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.757893146) |
| Ortholog in Animals | Alpaca_ CRTAM ( ortholog_one2one ) Dog_ CRTAM ( ortholog_one2one ) GuineaPig_ CRTAM ( ortholog_one2one ) Macaque_ CRTAM ( ortholog_one2one ) Mouse_ Crtam ( ortholog_one2one ) Pig_ CRTAM ( ortholog_one2one ) Rat_ Crtam ( ortholog_one2one ) Rabbit_ CRTAM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TIGIT, NCR3, CD200, NECTIN1, NECTIN2, CADM3, NECTIN4, CADM2, NECTIN3, CADM4, SMAGP, CADM1, CD226, PVR |
| Tissue | lymph.node, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 T-cells (PubMed:10811014, PubMed:15811952, PubMed:16300832). Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues (PubMed:16300832). {ECO:0000269|PubMed:10811014, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:16300832}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3RBG (X-ray 2.30A ) 4H5S (X-ray 1.70A ) |
| DBSNP | rs35411582 rs34397316 rs35136295 rs2272094 rs1916036 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q149L7}; Single-pass type I membrane protein {ECO:0000255}. Note=In a subset of CD4+ T-cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation. {ECO:0000250|UniProtKB:Q149L7}. |
| Mouse PG classification | NA |
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