| Gene Information | |
|---|---|
| Gene Name | SULT2B1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 365 |
| Protein Names | Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1) |
| Target Name | sulfotransferase family cytosolic 2b member 1 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000088002 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O00204 |
| Gene Card | SULT2B1 |
| Uniprot ID | O00204 |
| Pfam | PF00685 |
| In ASD | yes |
| Allosteric Prediction | yes (0.299067577) |
| Ortholog in Animals | Alpaca_ SULT2B1 ( ortholog_one2one ) Dog_ SULT2B1 ( ortholog_one2one ) GuineaPig_ SULT2B1 ( ortholog_one2one ) Macaque_ SULT2B1 ( ortholog_one2one ) Mouse_ Sult2b1 ( ortholog_one2one ) Pig_ SULT2B1 ( ortholog_one2one ) Rat_ Sult2b1 ( ortholog_one2one ) Rabbit_ SULT2B1 ( ortholog_one2one ) |
| Ohnologs | SULT4A1, SULT6B1, SULT1C3, SULT1C4, SULT1C2 |
| Paralogs | SULT1C2, SULT1B1, SULT1C3, SULT6B1, SULT1C4, SULT2A1, SULT1A2, SULT1A1, SULT1A4, SULT1A3, SULT1E1, SULT4A1 |
| Tissue | esophagus, skin, tongue, zone.of.skin, esophagus.mucosa, lower.leg.skin, suprapubic.skin, vagina |
| Tissue Specificity | Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level) (PubMed:28575648). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung (PubMed:9799594). {ECO:0000269|PubMed:28575648, ECO:0000269|PubMed:9799594}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1Q1Q (X-ray 2.91A ) 1Q1Z (X-ray 2.40A ) 1Q20 (X-ray 2.30A ) 1Q22 (X-ray 2.50A ) |
| DBSNP | rs16982149 rs1114167424 rs2302947 rs762765702 rs17842463 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:12923182, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:28575648}. Microsome {ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:21855633}. Nucleus {ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:21855633}. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus. {ECO:0000269|PubMed:21855633}. |
| Mouse PG classification | NA |
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