| Gene Information | |
|---|---|
| Gene Name | PRSS9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 244 |
| Protein Names | Kallikrein-6 (EC 3.4.21.-) (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q92876 |
| Gene Card | KLK6 |
| Uniprot ID | Q92876 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors. {ECO:0000269|PubMed:10997858, ECO:0000269|PubMed:11018688, ECO:0000269|PubMed:11668196, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:16800739}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1GVL (X-ray 1.80A ) 1L2E (X-ray 1.75A ) 1LO6 (X-ray 1.56A ) 3VFE (X-ray 1.88A ) 4D8N (X-ray 1.68A ) 5NX1 (X-ray 1.85A ) 5NX3 (X-ray 2.30A ) 6QFF (X-ray 1.64A ) 6QFG (X-ray 1.68A ) 6QFH (X-ray 1.65A ) 6QH9 (X-ray 2.27A ) 6QHA (X-ray 1.82A ) 6QHB (X-ray 1.84A ) 6QHC (X-ray 1.87A ) 6SKB (X-ray 1.84A ) 6SKC (X-ray 2.18A ) 6SKD (X-ray 2.26A ) |
| DBSNP | rs61469141 |
| Subcellular location [CC] | Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress. |
| Mouse PG classification | NA |
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