| Gene Information | |
|---|---|
| Gene Name | SDCBP |
| Organism | Homo sapiens (Human) |
| Gene Length | 298 |
| Protein Names | Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000137575 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O00560 |
| Gene Card | SDCBP |
| Uniprot ID | O00560 |
| Pfam | PF00595; PF02163 |
| In ASD | no |
| Allosteric Prediction | no (-0.174347035) |
| Ortholog in Animals | Alpaca_ SDCBP ( ortholog_one2one ) Dog_ SDCBP ( ortholog_one2many ) GuineaPig_ SDCBP ( ortholog_one2one ) Macaque_ SDCBP ( ortholog_one2one ) Mouse_ Sdcbp ( ortholog_one2one ) Pig_ SDCBP ( ortholog_one2one ) Rat_ Sdcbp ( ortholog_one2one ) Rabbit_ SDCBP ( ortholog_one2one ) |
| Ohnologs | SDCBP2 |
| Paralogs | APBA1, APBA2, APBA3, SDCBP2 |
| Tissue | NA |
| Tissue Specificity | Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta. {ECO:0000269|PubMed:25893292}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.066717(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1N99 (X-ray 1.94A ) 1NTE (X-ray 1.24A ) 1OBX (X-ray 1.35A ) 1OBY (X-ray 1.85A ) 1OBZ (X-ray 1.69A ) 1R6J (X-ray 0.73A ) 1V1T (X-ray 1.80A ) 1W9E (X-ray 1.56A ) 1W9O (X-ray 2.25A ) 1W9Q (X-ray 1.70A ) 1YBO (X-ray 2.30A ) 4Z33 (X-ray 2.45A ) 6R9H (X-ray 2.00A ) 6RLC (X-ray 2.20A ) |
| DBSNP | rs1127509 |
| Subcellular location [CC] | Cell junction, focal adhesion {ECO:0000269|PubMed:11179419}. Cell junction, adherens junction {ECO:0000269|PubMed:11179419}. Cell membrane {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:27386966}; Peripheral membrane protein {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:27386966}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:11179419}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cytoplasm, cytosol {ECO:0000269|PubMed:11179419}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11179419}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Membrane raft {ECO:0000269|PubMed:25893292}. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966). {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:27386966}. |
| Mouse PG classification | NA |
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