| Gene Information | |
|---|---|
| Gene Name | ZFAT |
| Organism | Homo sapiens (Human) |
| Gene Length | 1243 |
| Protein Names | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000066827 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9P243 |
| Gene Card | ZFAT |
| Uniprot ID | Q9P243 |
| Pfam | PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-1.005144136) |
| Ortholog in Animals | Alpaca_ ZFAT ( ortholog_one2one ) Dog_ ZFAT ( ortholog_one2one ) GuineaPig_ ZFAT ( ortholog_one2one ) Macaque_ ZFAT ( ortholog_one2one ) Mouse_ Zfat ( ortholog_one2one ) Pig_ ZFAT ( ortholog_one2one ) Rat_ Zfat ( ortholog_one2one ) Rabbit_ ZFAT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ZNF561, ZNF562, ZNF418, IKZF5, ZNF584, ZNF304, ZNF711, PRDM15, ZNF419, ZNF583, ZNF8, ZNF134, ZNF154, ZNF772, ZNF256, ZBTB11, ZNF549, ZNF587B, ZNF552, ZNF837, ZNF793, ZNF660, E4F1, ZNF773, ZNF79, ZSCAN20, ZNF551, ZSCAN2, ZNF610, ZNF480, ZFY, ZFX, ZIK1, ZNF792, ZNF548, ZNF691, ZNF586, ZNF570 |
| Tissue | placenta |
| Tissue Specificity | Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes. {ECO:0000269|PubMed:15294872}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2ELM (NMR - ) 2ELN (NMR - ) 2ELO (NMR - ) 2ELP (NMR - ) 2ELQ (NMR - ) 2ELR (NMR - ) 2ELS (NMR - ) 2ELT (NMR - ) 2ELU (NMR - ) 2ELV (NMR - ) 2RSH (NMR - ) 2RSI (NMR - ) 2RSJ (NMR - ) 2RUT (NMR - ) 2RUU (NMR - ) 2RUV (NMR - ) 2RUW (NMR - ) 2RUX (NMR - ) 2RUY (NMR - ) 2RUZ (NMR - ) 2RV0 (NMR - ) 2RV1 (NMR - ) 2RV2 (NMR - ) 2RV3 (NMR - ) 2RV6 (NMR - ) 2RV7 (NMR - ) |
| DBSNP | rs17778003 rs12541381 rs35003767 |
| Subcellular location [CC] | Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. |
| Mouse PG classification | NA |
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