| Gene Information | |
|---|---|
| Gene Name | FXR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 621 |
| Protein Names | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000114416 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P51114 |
| Gene Card | FXR1 |
| Uniprot ID | P51114 |
| Pfam | PF05641; PF12235; PF16096; PF16097; PF00013; PF17904; PF18336 |
| In ASD | no |
| Allosteric Prediction | no (-0.082055184) |
| Ortholog in Animals | Alpaca_ FXR1 ( ortholog_one2one ) Dog_ FXR1 ( ortholog_one2one ) GuineaPig_ FXR1 ( ortholog_one2one ) Macaque_ FXR1 ( ortholog_one2one ) Mouse_ Fxr1 ( ortholog_one2one ) Pig_ FXR1 ( ortholog_one2one ) Rat_ Fxr1 ( ortholog_one2one ) Rabbit_ FXR1 ( ortholog_one2one ) |
| Ohnologs | FMR1, FXR2 |
| Paralogs | FXR2, FMR1 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined including heart, brain, kidney and testis. {ECO:0000269|PubMed:7781595}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CPQ (NMR - ) 3KUF (X-ray 2.70A ) 3O8V (X-ray 2.50A ) |
| DBSNP | rs1051080 rs11499 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:7781595}. Note=Adjacent to Z-lines in muscles. {ECO:0000250|UniProtKB:Q61584}. |
| Mouse PG classification | NA |
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