| Gene Information | |
|---|---|
| Gene Name | ZDHHC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 367 |
| Protein Names | Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000104219 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UIJ5 |
| Gene Card | ZDHHC2 |
| Uniprot ID | Q9UIJ5 |
| Pfam | PF01529 |
| In ASD | no |
| Allosteric Prediction | no (-1.191812987) |
| Ortholog in Animals | Alpaca_ ZDHHC2 ( ortholog_one2one ) GuineaPig_ ZDHHC2 ( ortholog_one2one ) Macaque_ ZDHHC2 ( ortholog_one2one ) Mouse_ Zdhhc2 ( ortholog_one2one ) Pig_ ZDHHC2 ( ortholog_one2one ) Rat_ Zdhhc2 ( ortholog_one2one ) Rabbit_ ZDHHC2 ( ortholog_one2one ) |
| Ohnologs | ZDHHC15, ZDHHC20 |
| Paralogs | ZDHHC20, ZDHHC6, ZDHHC21, ZDHHC1, ZDHHC7, ZDHHC12, ZDHHC18, ZDHHC23, ZDHHC4, ZDHHC9, ZDHHC22, ZDHHC11, ZDHHC11B, ZDHHC3, ZDHHC15, ZDHHC14, ZDHHC19 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (PubMed:10918388, PubMed:22034844). Reduced expression in colorectal cancers with liver metastasis (PubMed:10918388). {ECO:0000269|PubMed:10918388, ECO:0000269|PubMed:22034844}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs568589179 |
| Subcellular location [CC] | Postsynaptic density {ECO:0000250|UniProtKB:Q9JKR5}. Postsynaptic recycling endosome membrane {ECO:0000250|UniProtKB:P59267}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21471008}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22034844}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:22034844}; Multi-pass membrane protein {ECO:0000255}. Note=Translocates to postsynaptic density when synaptic activity decreases. {ECO:0000250|UniProtKB:Q9JKR5}. |
| Mouse PG classification | NA |
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