| Gene Information | |
|---|---|
| Gene Name | CTNNA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 895 |
| Protein Names | Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000183230 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9UI47 |
| Gene Card | CTNNA3 |
| Uniprot ID | Q9UI47 |
| Pfam | PF01044 |
| In ASD | no |
| Allosteric Prediction | yes (0.104052494) |
| Ortholog in Animals | Alpaca_ CTNNA3 ( ortholog_one2one ) Dog_ CTNNA3 ( ortholog_one2one ) GuineaPig_ CTNNA3 ( ortholog_one2one ) Macaque_ CTNNA3 ( ortholog_one2one ) Mouse_ Ctnna3 ( ortholog_one2one ) Pig_ CTNNA3 ( ortholog_one2one ) Rat_ AABR07044900.1 ( ortholog_one2one ) Rabbit_ CTNNA3 ( ortholog_one2one ) |
| Ohnologs | CTNNA1, CTNNA2 |
| Paralogs | CTNNA1, CTNNA2, VCL, CTNNAL1 |
| Tissue | heart, testis |
| Tissue Specificity | Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:11590244}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs587777134 rs41274090 rs4548513 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000305}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q65CL1}. Note=Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. Colocalizes with PKP2 at intercalated disks in the heart (By similarity). {ECO:0000250|UniProtKB:Q65CL1, ECO:0000269|PubMed:11590244}. |
| Mouse PG classification | HPG |
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