| Gene Information | |
|---|---|
| Gene Name | ZC4H2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 224 |
| Protein Names | Zinc finger C4H2 domain-containing protein (Hepatocellular carcinoma-associated antigen 127) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000126970 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NQZ6 |
| Gene Card | ZC4H2 |
| Uniprot ID | Q9NQZ6 |
| Pfam | PF10146 |
| In ASD | no |
| Allosteric Prediction | no (-1.715004388) |
| Ortholog in Animals | Alpaca_ ZC4H2 ( ortholog_one2one ) Dog_ ZC4H2 ( ortholog_one2one ) Macaque_ ZC4H2 ( ortholog_one2one ) Mouse_ Zc4h2 ( ortholog_one2one ) Pig_ ZC4H2 ( ortholog_one2one ) Rat_ Zc4h2 ( ortholog_one2one ) Rabbit_ ZC4H2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in fetal tissues, including in brain, intestine, lung, kidney and muscle (PubMed:23623388). Isoform 1 is expressed in numerous fetal brain regions. Isoform 3 is highly expressed in numerous fetal brain regions and spinal cord (PubMed:26056227). {ECO:0000269|PubMed:23623388}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1057520299 rs398122938 rs1057520297 rs879255235 rs1929006117 rs398122939 rs1064795753 rs879255236 rs1929002470 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:23623388}. Nucleus {ECO:0000269|PubMed:23623388, ECO:0000269|PubMed:26056227}. Postsynaptic cell membrane {ECO:0000269|PubMed:23623388}. Note=Upon transfection into mouse primary hippocampal neurons, localizes at excitatory, but not inhibitory, postsynaptic sites. |
| Mouse PG classification | NA |
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