| Gene Information | |
|---|---|
| Gene Name | MGRN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 552 |
| Protein Names | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000102858 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60291 |
| Gene Card | MGRN1 |
| Uniprot ID | O60291 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.535792976) |
| Ortholog in Animals | Alpaca_ MGRN1 ( ortholog_one2one ) Dog_ MGRN1 ( ortholog_one2one ) GuineaPig_ MGRN1 ( ortholog_one2one ) Macaque_ MGRN1 ( ortholog_one2one ) Mouse_ Mgrn1 ( ortholog_one2one ) Pig_ MGRN1 ( ortholog_one2one ) Rat_ Mgrn1 ( ortholog_one2one ) Rabbit_ MGRN1 ( ortholog_one2one ) |
| Ohnologs | RNF157 |
| Paralogs | RNF157 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Early endosome {ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19737927}. Note=The endosomal localization is dependent on the interaction with TSG101.; [Isoform 1]: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 2]: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 3]: Cytoplasm, cytosol. Cell membrane.; [Isoform 4]: Cytoplasm, cytosol. Cell membrane. |
| Mouse PG classification | NA |
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