| Gene Information | |
|---|---|
| Gene Name | ZBTB49 |
| Organism | Homo sapiens (Human) |
| Gene Length | 765 |
| Protein Names | Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000168826 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q6ZSB9 |
| Gene Card | ZBTB49 |
| Uniprot ID | Q6ZSB9 |
| Pfam | PF00651; PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-0.465257763) |
| Ortholog in Animals | Alpaca_ ZBTB49 ( ortholog_one2one ) Dog_ ZBTB49 ( ortholog_one2one ) GuineaPig_ ZBTB49 ( ortholog_one2one ) Macaque_ ZBTB49 ( ortholog_one2one ) Mouse_ Zbtb49 ( ortholog_one2one ) Pig_ ZBTB49 ( ortholog_one2one ) Rat_ Zbtb49 ( ortholog_one2one ) Rabbit_ ZBTB49 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FEZF1, PRDM12, ZNF280A, ZBTB33, ZBTB21, ZNF280C, NACC2, ZNF580, ZBTB26, NACC1, ZNF683, ZBTB7B, GFI1, PRDM13, ZNF280B, ZBTB6, ZBTB14, GFI1B, BCL6, BCL6B, ZBTB3, ZNF581, FEZF2, ZNF280D, ZBTB46, ZNF524, ZBTB12, ZBTB25 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in normal epidermis and in other epithelial tissues, including in colon and lung. Tends to be down-regulated in colon, lung and skin cancer tissues. {ECO:0000269|PubMed:25245946}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2920217 rs4689254 rs146575965 rs34293093 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:25245946}. Nucleus {ECO:0000269|PubMed:25245946}. Note=Predominantly located in the nucleus. {ECO:0000269|PubMed:25245946}.; [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:25245946}. Nucleus {ECO:0000269|PubMed:25245946}. |
| Mouse PG classification | NA |
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