| Gene Information | |
|---|---|
| Gene Name | ATG16L1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 607 |
| Protein Names | Autophagy-related protein 16-1 (APG16-like 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000085978 ) 3 ( ENSG00000281089 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q676U5 |
| Gene Card | ATG16L1 |
| Uniprot ID | Q676U5 |
| Pfam | PF08614; PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.000801527) |
| Ortholog in Animals | Alpaca_ ATG16L1 ( ortholog_one2one ) Dog_ ATG16L1 ( ortholog_one2one ) GuineaPig_ ATG16L1 ( ortholog_one2one ) Macaque_ ATG16L1 ( ortholog_one2one ) Mouse_ Atg16l1 ( ortholog_one2one ) Pig_ ATG16L1 ( ortholog_one2one ) Rat_ Atg16l1 ( ortholog_one2one ) Rabbit_ ATG16L1 ( ortholog_one2one ) |
| Ohnologs | ATG16L2 |
| Paralogs | ATG16L2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.03952(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4GDK (X-ray 2.70A ) 4GDL (X-ray 2.88A ) 4NAW (X-ray 2.20A ) 4TQ0 (X-ray 2.70A ) 5D7G (X-ray 3.00A ) 5NPV (X-ray 3.10A ) 5NPW (X-ray 3.10A ) 5NUV (X-ray 1.55A ) 5ZYX (NMR - ) |
| DBSNP | rs2241880 rs1866878 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:23392225}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:23392225}; Peripheral membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:29317426}; Peripheral membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:29317426}; Peripheral membrane protein {ECO:0000305}. Note=Recruited to omegasomes membranes by WIPI2 (By similarity). Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (By similarity). Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). Upon activation of non-canonical autophagy, recruited to single-membrane endolysosomal compartments (PubMed:29317426). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:29317426}. |
| Mouse PG classification | NA |
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