Gene Information

Gene Information
Gene Name	POLH
Organism	Homo sapiens (Human)
Gene Length	713
Protein Names	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein)
Target Name	NA
Target Type	NA
Gene Age	1292 ( ENSG00000170734 )
Evolutionary Stage	Eukaryota
AlphaFoldDB	Q9Y253
Gene Card	POLH
Uniprot ID	Q9Y253
Pfam	PF00817; PF11799; PF18439
In ASD	no
Allosteric Prediction	no (-0.293531066)
Ortholog in Animals	Alpaca_ POLH ( ortholog_one2one ) Dog_ POLH ( ortholog_one2one ) GuineaPig_ POLH ( ortholog_one2one ) Macaque_ POLH ( ortholog_one2one ) Mouse_ Polh ( ortholog_one2one ) Pig_ POLH ( ortholog_one2one ) Rat_ Polh ( ortholog_one2one ) Rabbit_ POLH ( ortholog_one2one )
Ohnologs	NA
Paralogs	REV1, POLI, ESCO1, ESCO2, POLK
Tissue	NA
Tissue Specificity	NA
Pharmacological Animal Models	NULL(Chimpanzee);NULL(Mouse);0.002865(Rat);NULL(Rabbit)
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	2I5O (NMR - ) 2LSK (NMR - ) 3JAA (EM 22.00A ) 3MR2 (X-ray 1.83A ) 3MR3 (X-ray 1.75A ) 3MR5 (X-ray 1.80A ) 3MR6 (X-ray 1.90A ) 3SI8 (X-ray 2.15A ) 3TQ1 (X-ray 2.56A ) 3WUP (X-ray 1.60A ) 4DL2 (X-ray 2.15A ) 4DL3 (X-ray 2.10A ) 4DL4 (X-ray 2.00A ) 4DL5 (X-ray 2.92A ) 4DL6 (X-ray 2.50A ) 4DL7 (X-ray 1.97A ) 4ECQ (X-ray 1.50A ) 4ECR (X-ray 1.89A ) 4ECS (X-ray 1.95A ) 4ECT (X-ray 1.80A ) 4ECU (X-ray 1.95A ) 4ECV (X-ray 1.52A ) 4ECW (X-ray 1.90A ) 4ECX (X-ray 1.74A ) 4ECY (X-ray 1.94A ) 4ECZ (X-ray 1.83A ) 4ED0 (X-ray 1.65A ) 4ED1 (X-ray 1.81A ) 4ED2 (X-ray 1.71A ) 4ED3 (X-ray 1.79A ) 4ED6 (X-ray 2.21A ) 4ED7 (X-ray 1.72A ) 4ED8 (X-ray 1.52A ) 4EEY (X-ray 2.32A ) 4J9K (X-ray 2.03A ) 4J9L (X-ray 1.85A ) 4J9M (X-ray 2.25A ) 4J9N (X-ray 1.96A ) 4J9O (X-ray 2.60A ) 4J9P (X-ray 2.30A ) 4J9Q (X-ray 1.96A ) 4J9R (X-ray 2.35A ) 4J9S (X-ray 1.95A ) 4O3N (X-ray 1.58A ) 4O3O (X-ray 1.70A ) 4O3P (X-ray 1.72A ) 4O3Q (X-ray 1.72A ) 4O3R (X-ray 1.62A ) 4O3S (X-ray 1.72A ) 4Q8E (X-ray 1.55A ) 4Q8F (X-ray 2.80A ) 4RNM (X-ray 2.14A ) 4RNN (X-ray 1.81A ) 4RNO (X-ray 2.82A ) 4RU9 (X-ray 2.65A ) 4YP3 (X-ray 1.89A ) 4YQW (X-ray 2.06A ) 4YR0 (X-ray 1.78A ) 4YR2 (X-ray 1.95A ) 4YR3 (X-ray 2.00A ) 5DG7 (X-ray 2.26A ) 5DG8 (X-ray 2.12A ) 5DG9 (X-ray 2.15A ) 5DGA (X-ray 2.30A ) 5DGB (X-ray 1.79A ) 5DLF (X-ray 1.97A ) 5DLG (X-ray 2.35A ) 5DQG (X-ray 2.29A ) 5DQH (X-ray 1.99A ) 5DQI (X-ray 2.30A ) 5EWE (X-ray 1.66A ) 5EWF (X-ray 1.78A ) 5EWG (X-ray 1.75A ) 5F9L (X-ray 2.59A ) 5F9N (X-ray 2.23A ) 5JUM (X-ray 2.60A ) 5KFA (X-ray 1.51A ) 5KFB (X-ray 1.55A ) 5KFC (X-ray 1.50A ) 5KFD (X-ray 1.65A ) 5KFE (X-ray 1.55A ) 5KFF (X-ray 1.70A ) 5KFG (X-ray 1.55A ) 5KFH (X-ray 1.72A ) 5KFI (X-ray 1.65A ) 5KFJ (X-ray 1.70A ) 5KFK (X-ray 1.70A ) 5KFL (X-ray 1.65A ) 5KFM (X-ray 1.60A ) 5KFN (X-ray 1.45A ) 5KFO (X-ray 1.52A ) 5KFP (X-ray 1.70A ) 5KFQ (X-ray 1.55A ) 5KFR (X-ray 1.75A ) 5KFS (X-ray 1.46A ) 5KFT (X-ray 1.52A ) 5KFU (X-ray 1.55A ) 5KFV (X-ray 1.60A ) 5KFW (X-ray 1.62A ) 5KFX (X-ray 1.52A ) 5KFY (X-ray 1.70A ) 5KFZ (X-ray 1.44A ) 5KG0 (X-ray 1.60A ) 5KG1 (X-ray 1.62A ) 5KG2 (X-ray 1.60A ) 5KG3 (X-ray 1.70A ) 5KG4 (X-ray 1.60A ) 5KG5 (X-ray 1.60A ) 5KG6 (X-ray 1.55A ) 5KG7 (X-ray 1.75A ) 5L1I (X-ray 2.78A ) 5L1J (X-ray 1.94A ) 5L1K (X-ray 1.82A ) 5L1L (X-ray 1.62A ) 5L9X (X-ray 1.90A ) 6D0M (X-ray 1.83A ) 6D0Z (X-ray 1.75A ) 6M7O (X-ray 3.00A ) 6M7P (X-ray 1.75A ) 6M7T (X-ray 2.80A ) 6M7U (X-ray 3.40A ) 6M7V (X-ray 3.06A ) 6MP3 (X-ray 1.91A ) 6MQ8 (X-ray 1.97A ) 6MXO (X-ray 2.04A ) 6PL7 (X-ray 2.50A ) 6PL8 (X-ray 2.17A ) 6PLC (X-ray 2.50A ) 6PZ3 (X-ray 2.40A ) 6Q02 (X-ray 2.09A ) 6UI2 (X-ray 2.35A ) 6UQI (X-ray 2.50A ) 6V5K (X-ray 2.69A ) 6W5X (X-ray 2.59A ) 6WK6 (X-ray 2.35A ) 7L69 (X-ray 1.91A ) 7LCD (X-ray 1.98A ) 7M7L (X-ray 1.58A ) 7M7M (X-ray 1.46A ) 7M7N (X-ray 1.31A ) 7M7O (X-ray 1.80A ) 7M7P (X-ray 1.80A ) 7M7Q (X-ray 2.27A ) 7M7R (X-ray 1.81A ) 7M7S (X-ray 1.85A ) 7M7T (X-ray 1.46A ) 7M7U (X-ray 1.94A ) 7M7Y (X-ray 1.80A ) 7M7Z (X-ray 1.82A ) 7M80 (X-ray 1.98A ) 7M81 (X-ray 2.05A ) 7M82 (X-ray 2.07A ) 7M83 (X-ray 1.55A ) 7M84 (X-ray 1.47A ) 7M85 (X-ray 1.75A ) 7M86 (X-ray 1.55A ) 7M87 (X-ray 1.85A ) 7M88 (X-ray 1.66A ) 7M89 (X-ray 1.83A ) 7M8A (X-ray 1.91A ) 7M8B (X-ray 1.85A ) 7M8C (X-ray 1.85A ) 7M8D (X-ray 1.92A ) 7U72 (X-ray 1.53A ) 7U73 (X-ray 1.56A ) 7U74 (X-ray 1.52A ) 7U75 (X-ray 1.55A ) 7U76 (X-ray 1.69A ) 7U77 (X-ray 1.58A ) 7U78 (X-ray 1.61A ) 7U79 (X-ray 1.69A ) 7U7A (X-ray 1.58A ) 7U7B (X-ray 1.58A ) 7U7C (X-ray 1.55A ) 7U7D (X-ray 1.57A ) 7U7E (X-ray 1.58A ) 7U7F (X-ray 1.65A ) 7U7G (X-ray 1.77A ) 7U7I (X-ray 1.57A ) 7U7J (X-ray 1.58A ) 7U7K (X-ray 1.67A ) 7U7L (X-ray 1.47A ) 7U7R (X-ray 1.64A ) 7U7S (X-ray 1.60A ) 7U7T (X-ray 1.55A ) 7U7U (X-ray 1.54A ) 7U7V (X-ray 1.65A ) 7U7W (X-ray 1.66A ) 7U7X (X-ray 1.65A ) 7U7Y (X-ray 1.78A ) 7U7Z (X-ray 1.67A ) 7U80 (X-ray 1.83A ) 7U81 (X-ray 1.60A ) 7U82 (X-ray 1.55A ) 7U83 (X-ray 1.55A ) 7U84 (X-ray 1.71A )
DBSNP	rs756931657 rs758423288 rs1561900151 rs367709714 rs2307456 rs1413703153 rs9333548 rs9296419 rs56307355 rs9333554 rs121908565 rs9333555 rs6941583 rs199562456
Subcellular location [CC]	Nucleus {ECO:0000269\|PubMed:12606586, ECO:0000269\|PubMed:16357261, ECO:0000269\|PubMed:22801543, ECO:0000269\|PubMed:24553286}. Note=Binding to ubiquitinated PCNA mediates colocalization to replication foci during DNA replication and persists at sites of stalled replication forks following UV irradiation (PubMed:12606586, PubMed:16357261, PubMed:24553286). After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80%; this recruitment may not be not restricted to cells active in DNA replication (PubMed:22801543). Colocalizes with TRAIP to nuclear foci (PubMed:24553286). {ECO:0000269\|PubMed:12606586, ECO:0000269\|PubMed:16357261, ECO:0000269\|PubMed:22801543, ECO:0000269\|PubMed:24553286}.
Mouse PG classification	HPG
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