| Gene Information | |
|---|---|
| Gene Name | ZAP70 |
| Organism | Homo sapiens (Human) |
| Gene Length | 619 |
| Protein Names | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) |
| Target Name | tyrosine-protein kinase zap-70 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000115085 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P43403 |
| Gene Card | ZAP70 |
| Uniprot ID | P43403 |
| Pfam | PF07714; PF00017 |
| In ASD | yes |
| Allosteric Prediction | yes (1.124009299) |
| Ortholog in Animals | Alpaca_ ZAP70 ( ortholog_one2one ) Dog_ ZAP70 ( ortholog_one2one ) GuineaPig_ ZAP70 ( ortholog_one2one ) Macaque_ ZAP70 ( ortholog_one2one ) Mouse_ Zap70 ( ortholog_one2one ) Rat_ Zap70 ( ortholog_one2one ) Rabbit_ ZAP70 ( ortholog_one2one ) |
| Ohnologs | SYK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Expressed in T- and natural killer cells. Also present in early thymocytes and pro/pre B-cells. {ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:16467082, ECO:0000269|PubMed:9378960}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.069565(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1FBV (X-ray 2.90A ) 1M61 (X-ray 2.50A ) 1U59 (X-ray 2.30A ) 2CBL (X-ray 2.10A ) 2OQ1 (X-ray 1.90A ) 2OZO (X-ray 2.60A ) 2Y1N (X-ray 2.00A ) 3ZNI (X-ray 2.21A ) 4A4B (X-ray 2.79A ) 4A4C (X-ray 2.70A ) 4K2R (X-ray 3.00A ) 4XZ0 (X-ray 2.00A ) 4XZ1 (X-ray 2.80A ) 5O76 (X-ray 2.47A ) |
| DBSNP | rs55964305 rs56403250 rs199840952 rs1254428002 rs869025224 rs113994174 rs137853201 rs104893674 rs56189815 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9813084}. Cell membrane {ECO:0000269|PubMed:9813084}; Peripheral membrane protein {ECO:0000269|PubMed:9813084}. Note=In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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