| Gene Information | |
|---|---|
| Gene Name | ZAK |
| Organism | Homo sapiens (Human) |
| Gene Length | 800 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) |
| Target Name | mitogen-activated protein kinase kinase kinase mlt |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NYL2 |
| Gene Card | MAP3K20 |
| Uniprot ID | Q9NYL2 |
| Pfam | PF07714; PF00536 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Isoform ZAKbeta is the predominant form in all tissues examined, except for liver, in which isoform ZAKalpha is more highly expressed. {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11836244}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 5HES (X-ray 2.14A ) 5X5O (X-ray 1.87A ) 6JUT (X-ray 2.10A ) 6JUU (X-ray 1.90A ) |
| DBSNP | rs763481300 rs6758025 rs34683477 rs863225437 rs3769148 rs7593622 rs56202258 rs35608243 rs55830025 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15684425}. Nucleus {ECO:0000269|PubMed:15684425}. Note=Translocates to the nucleus upon ultraviolet B irradiation. {ECO:0000269|PubMed:15684425}. |
| Mouse PG classification | NA |
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