Gene Information
Gene NameCAPN5
OrganismHomo sapiens (Human)
Gene Length640
Protein NamesCalpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000149260 )
Evolutionary StageEukaryota
AlphaFoldDBO15484
Gene CardCAPN5
Uniprot IDO15484
PfamPF00168; PF01067; PF00648
In ASDno
Allosteric Predictionno (-0.508661559)
Ortholog in AnimalsAlpaca_ CAPN5 ( ortholog_one2one )
Dog_ CAPN5 ( ortholog_one2one )
GuineaPig_ CAPN5 ( ortholog_one2one )
Macaque_ CAPN5 ( ortholog_one2one )
Mouse_ Capn5 ( ortholog_one2one )
Pig_ CAPN5 ( ortholog_one2one )
Rat_ Capn5 ( ortholog_one2one )
Rabbit_ CAPN5 ( ortholog_one2one )
OhnologsCAPN6
ParalogsCAPN1, PEF1, GCA, SRI, CAPN9, PDCD6, CAPN2, CAPN14, CAPN15, CAPN7, ADGB, CAPN6, CAPN8, CAPN3, CAPN12, CAPNS2, CAPN11, CAPN13, CAPNS1, CAPN10
TissueNA
Tissue SpecificityExpressed in many tissues. Strong expression in the photoreceptor cells of the retina, with a punctate pattern of labeling over the nuclei and inner segments with less expression along the other segments and outer plexiform layer. {ECO:0000269|PubMed:23055945}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6P3Q  (X-ray  2.80A 
DBSNP rs397514601  rs397514602 
Subcellular location [CC]NA
Mouse PG classificationLPG
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