| Gene Information | |
|---|---|
| Gene Name | YTHDF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 579 |
| Protein Names | YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000198492 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y5A9 |
| Gene Card | YTHDF2 |
| Uniprot ID | Q9Y5A9 |
| Pfam | PF04146 |
| In ASD | no |
| Allosteric Prediction | no (-0.370308205) |
| Ortholog in Animals | Alpaca_ YTHDF2 ( ortholog_one2one ) Dog_ YTHDF2 ( ortholog_one2one ) GuineaPig_ YTHDF2 ( ortholog_one2one ) Macaque_ YTHDF2 ( ortholog_one2one ) Mouse_ Ythdf2 ( ortholog_one2one ) Pig_ YTHDF2 ( ortholog_one2one ) Rat_ Ythdf2 ( ortholog_one2one ) Rabbit_ YTHDF2 ( ortholog_one2one ) |
| Ohnologs | YTHDF1, YTHDF3 |
| Paralogs | YTHDF1, YTHDC1, YTHDF3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in induced pluripotent stem cells (iPSCs) and down-regulated during neural differentiation. {ECO:0000269|PubMed:32169943}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4RDN (X-ray 2.10A ) 4RDO (X-ray 2.15A ) 4WQN (X-ray 2.12A ) 7A1V (X-ray 2.20A ) 7BIK (X-ray 2.10A ) 7R5F (X-ray 2.00A ) 7R5L (X-ray 1.70A ) 7R5W (X-ray 1.75A ) 7YWB (X-ray 1.92A ) 7YX6 (X-ray 1.80A ) 7YXE (X-ray 1.85A ) 7Z26 (X-ray 1.90A ) 7Z4U (X-ray 1.83A ) 7Z54 (X-ray 1.82A ) 7Z5M (X-ray 1.70A ) 7Z7B (X-ray 1.80A ) 7Z7F (X-ray 1.95A ) 7Z8P (X-ray 1.97A ) 7Z8W (X-ray 1.90A ) 7Z8X (X-ray 1.96A ) 7Z92 (X-ray 1.91A ) 7Z93 (X-ray 1.97A ) 7ZG4 (X-ray 2.01A ) |
| DBSNP | rs16838382 rs35288745 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:32492408}. Cytoplasm, P-body {ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:32492408}. Cytoplasm, Stress granule {ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:32451507}. Nucleus {ECO:0000269|PubMed:26458103}. Note=Localizes to the cytosol and relocates to the nucleus following heat shock stress (PubMed:26458103). Can partition into different structures: into P-bodies in unstressed cells, and into stress granules during stress (PubMed:31292544). {ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:31292544}. |
| Mouse PG classification | NA |
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